Dynamic Signaling in the Hog1 MAPK Pathway Relies on High Basal Signal Transduction

Science Signaling  24 Mar 2009:
Vol. 2, Issue 63, pp. ra13
DOI: 10.1126/scisignal.2000056

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Intrinsically Responsive

Macia et al. found that when the activity of the mitogen-activated protein kinase (MAPK), Hog1, was inhibited, the phosphorylated form of this MAPK accumulated, suggesting that signaling occurs even in the absence of stress. The basal signaling was found to be held in check by a negative feedback loop that required the kinase activity of Hog1. A model of the system that included the basal signal and the negative feedback recapitulated the experimental data and suggested that intrinsic basal signaling poises the system to respond rapidly even to small changes in osmolarity. A similar basal activity was also detected for two additional yeast MAPKs, those involved in the pheromone response, suggesting that high basal signaling may be a common property of MAPK pathways.

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