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COVER This week's issue features a Perspective that discusses the shedding of the extracellular portion (ectodomain) of syndecan transmembrane proteoglycans. The image shows that shed syndecan ectodomains sequester the ligands for growth factor and chemokine receptors, thereby inhibiting signaling through these receptors. [Image: Preston Huey, AAAS]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882