Research ArticleImmunology

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

Sci. Signal.  07 Apr 2009:
Vol. 2, Issue 65, pp. ra15
DOI: 10.1126/scisignal.2000199

You are currently viewing the editor's summary.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

Right Times and Right Places

Signals downstream of receptor activation can be effectively regulated by controlling both the distribution of signaling intermediates within the cell and the time at which they get to their destinations. Such spatiotemporal patterning of receptors, kinases, and adaptor molecules can have a substantial effect on their local concentrations and on the probabilities that they will interact with each other. Previous studies have characterized the patterning of individual or small groups of molecules; however, systems-level analyses of such processes are lacking. Singleton et al. have studied the spatiotemporal patterning of some 30 signaling intermediates in various mouse T cells activated by antigen-presenting cells under different conditions. As well as establishing that the patterning of these molecules regulates the efficiency of T cell receptor signaling, this study also shows that different T cell activation conditions generate different spatiotemporal patterns.

Cited By...