Nontraditional Signaling Mechanisms of Lipoprotein Receptors

Science Signaling  28 Apr 2009:
Vol. 2, Issue 68, pp. pe28
DOI: 10.1126/scisignal.268pe28

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The low-density lipoprotein receptor family consists of a large number of single transmembrane proteins that are involved both in endocytosis of extracellular ligands and in intracellular signaling processes. New evidence ties these receptors to the transactivation of Trk receptors. Thus, this single receptor family demonstrates several distinct mechanisms for transducing information across the plasma membrane.

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