PerspectiveNeuroscience

Fragile Axons Forge the Path to Gene Discovery: A MAP Kinase Pathway Regulates Axon Regeneration

See allHide authors and affiliations

Sci. Signal.  05 May 2009:
Vol. 2, Issue 69, pp. pe30
DOI: 10.1126/scisignal.269pe30

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The nematode Caenorhabditis elegans is emerging as a promising model for studying the molecular control of axon regeneration. A forward genetic screen identified the DLK-1 (dual leucine zipper-bearing kinase 1) MAP (mitogen-activated protein) kinase pathway as a positive regulator of growth cone formation during axon regeneration. Although DLK-1 pathway mutant animals display a dramatic defect in regeneration, their axons have no apparent defects in initial outgrowth. The DLK-1 pathway also plays a role in synaptogenesis, but this role appears to be separate from its function in regeneration. Understanding how the DLK-1 pathway acts in development, plasticity, and regeneration may shed light on the evolution of mechanisms regulating axon regeneration.

View Full Text