Contents
Vol 2, Issue 81
Contents
Editorial Guide
- Focus Issue: Unraveling Signaling Complexity
Dynamics adds to the complexity of signaling networks.
Research Articles
- Cell Type–Specific Importance of Ras–c-Raf Complex Association Rate Constants for MAPK Signaling
Ras–c-Raf association rates affect downstream signaling in the absence of negative feedback but not its presence.
- Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases
Comparing the human phosphoproteome to that of flies, worms, and yeast reveals insight into evolution and disease.
- Integrating Proteomic, Transcriptional, and Interactome Data Reveals Hidden Components of Signaling and Regulatory Networks
Analysis of multiple “omic” data sets with a prize-collecting Steiner tree algorithm reveals components of signaling networks that are not obvious by analyzing the data individually.
Perspectives
- Understanding Modularity in Molecular Networks Requires Dynamics
Relating structure and dynamics of molecular networks remains very challenging.
- Proteomic Revelation: SUMO Changes Partners When the Heat Is On
A system-level view of SUMOylation dynamics shows the importance of SUMOylation to the heat shock response.
- The Complexity of Cell Signaling and the Need for a New Mechanics
Studies that make sense of protein networks provide approaches to cope with complex signaling pathways.
- Dynamic Advances in NF-κB Signaling Analysis
Cytokine stimulation of cells at different time intervals produce distinct patterns of NF-κB–dependent gene transcription.
Podcast
- Science Signaling Podcast: 28 July 2009
Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.
Editors' Choice
- Integrin Integral to Innate Immunity
Integrins launch innate immune responses to invading adenovirus.
- More Than Meets the Eye
The transcriptional coactivator and tyrosine phosphatase EYA4 also acts as a threonine phosphatase to enhance innate immune responses.
- Switching Macrophage Responses
ATP has both a proinflammatory action and an anti-inflammatory action in macrophages.
- Multiple Mechanisms of Inflammation
Different TLRs elicit target gene derepression through distinct signaling pathways.
- Master Controller
Coordination of the genes that regulate lysosomal biogenesis occurs via a shared sequence motif and one transcription factor.
- Keeping Calm
Possible drug alternative for rapid treatment of anxiety disorders could replace benzodiazepines.
- Transforming Hyperglycemia into Hypertrophy
TGF-β signaling through the mTOR pathway is critical to glucose-induced cellular hypertrophy.
