PerspectiveCell Biology

Dynamic Advances in NF-κB Signaling Analysis

Sci. Signal.  28 Jul 2009:
Vol. 2, Issue 81, pp. pe47
DOI: 10.1126/scisignal.281pe47

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Abstract

Signaling through the transcription factor nuclear factor κB (NF-κB) regulates various physiological processes, including immune responses and inflammation. An analysis of NF-κB dynamics suggests that the oscillation frequency of NF-κB activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways.

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