Posttranslational modification

Lysine Acetylation Catalog

Science Signaling  18 Aug 2009:
Vol. 2, Issue 84, pp. ec275
DOI: 10.1126/scisignal.284ec275

Covalent posttranslational modification is an essential cellular regulatory mechanism by which the activity of proteins can be controlled. Advances in mass spectrometry made it possible for Choudhary et al. to assess the prevalence of lysine acetylation throughout the whole proteome. Acetylation is much more widespread than previously appreciated and occurs on proteins participating in all sorts of biological functions. Acetylation can influence susceptibility of proteins to phosphorylation and occurs frequently on enzymes that control the modification of other proteins by covalent ubiquitination and on proteins that form large macromolecular complexes. The findings also help to characterize the actions of lysine deacetylase inhibitors, which have shown clinical promise in treatments for cancer.

C. Choudhary, C. Kumar, F. Gnad, M. L. Nielsen, M. Rehman, T. C. Walther, J. V. Olsen, M. Mann, Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834–840 (2009). [Abstract] [Full Text]