PerspectiveNuclear Receptors

miRNA Regulation Through Ligand Occupancy of a Nuclear Hormone Receptor

See allHide authors and affiliations

Sci. Signal.  18 Aug 2009:
Vol. 2, Issue 84, pp. pe52
DOI: 10.1126/scisignal.284pe52

You are currently viewing the abstract.

View Full Text


MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.

View Full Text