Oncogenic EGFR Signaling Networks in Glioma

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Sci. Signal.  08 Sep 2009:
Vol. 2, Issue 87, pp. re6
DOI: 10.1126/scisignal.287re6

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The epidermal growth factor receptor (EGFR) is a transmembrane protein that regulates many fundamental cellular processes, including growth, survival, and migration. EGFR is amplified, overexpressed, or mutated in various types of cancer, resulting in the deregulation of these critical cellular processes. In this Review, which has four figures and 120 citations, we examine the mechanisms by which EGFR contributes to oncogenic transformation in an aggressive form of brain tumor (glioblastoma) and discuss the limitations of current treatment strategies. Finally, we offer an outlook on how these therapies may be improved through the use of systems biology.