STAT3 Revs Up the Powerhouse

Sci. Signal., 29 September 2009
Vol. 2, Issue 90, p. pe61
DOI: 10.1126/scisignal.290pe61

STAT3 Revs Up the Powerhouse

  1. Nancy C. Reich*
  1. Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.
  1. *Corresponding author. E-mail, nancy.reich{at}


Tyrosine phosphorylation of signal transducers and activators of transcription (STATs) promotes their dimerization and ability to bind target genes in the nucleus. However, evidence shows that one member of the STAT family, STAT3, has an additional property independent of its classical role in the nucleus. STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras.


N. C. Reich, STAT3 Revs Up the Powerhouse. Sci. Signal. 2, pe61 (2009).

Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody
M. Y. Koo, J. Park, J. M. Lim, S. Y. Joo, S.-P. Shin, H. B. Shim, J. Chung, D. Kang, H. A. Woo, S. G. Rhee et al.
Proc. Natl. Acad. Sci. USA 111, 6269-6274 (29 April 2014)

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype
C. Mantel, S. Messina-Graham, A. Moh, S. Cooper, G. Hangoc, X.-Y. Fu, and H. E. Broxmeyer
Blood 120, 2589-2599 (27 September 2012)

Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies
P. Sansone, and J. Bromberg
JCO 30, 1005-1014 (20 March 2012)

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