Mimicking Caloric Restriction

Sci. Signal.  06 Oct 2009:
Vol. 2, Issue 91, pp. ec327
DOI: 10.1126/scisignal.291ec327

The extended life span and resistance to age-related diseases in animals exposed to caloric restriction have focused attention on the biochemical mechanisms that produce these effects. Selman et al. (see the Perspective by Kaeberlein and Kapahi) explored the role of the mammalian ribosomal protein S6 kinase 1 (S6K1), which regulates protein translation and cellular energy metabolism. Female knockout mice lacking expression of S6K1 showed characteristics of animals exposed to caloric restriction, including improved health and increased longevity. The beneficial effects included reduced fat mass despite increased food intake. Thus, inhibition of signaling pathways activated by S6K1 might prove beneficial in protecting against age-related disease.

C. Selman, J. M. A. Tullet, D. Wieser, E. Irvine, S. J. Lingard, A. I. Choudhury, M. Claret, H. Al-Qassab, D. Carmignac, F. Ramadani, A. Woods, I. C. A. Robinson, E. Schuster, R. L. Batterham, S. C. Kozma, G. Thomas, D. Carling, K. Okkenhaug, J. M. Thornton, L. Partridge, D. Gems, D. J. Withers, Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140–144 (2009). [Abstract] [Full Text]

M. Kaeberlein, P. Kapahi, Aging is RSKy business. Science 326, 55–56 (2009). [Summary] [Full Text]