Editors' ChoiceNuclear Receptors

Androgen Receptor Partner

Science's STKE  11 Jan 2000:
Vol. 2000, Issue 14, pp. tw5
DOI: 10.1126/stke.2000.14.tw5

Androgen receptors are members of the nuclear receptor superfamily of ligand-activated transcription factors. Lee et al. describe an expanded regulatory role for androgen receptors that results from their interaction with another nuclear receptor—human testicular orphan receptor-4 (TR4 is an 'orphan' in the sense that its ligand remains unknown). Interaction of AR and TR4 inhibits binding of TR4 to target genes and thus decreases expression of genes normally regulated by TR4. Conversely, binding of TR4 to AR appears to inhibit transcription stimulated by the AR. Thus the spectrum of genes regulated by ARs is expanded to include genes targeted by TR4. And the effects of TR4 reveal a new mechanism for regulation of AR signaling. The authors suggest that, eventually, understanding of these regulatory interactions may lead to development of new therapeutic agents to enhance or inhibit androgen signaling.

Lee, Y.F., Shyr, C.-R., Thin, T.H., Lin, W.-J., and Chang, C. (1999) Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: A unique signaling pathway in the steroid receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 96:14724-14729. [Abstract] [Full Text]