Editors' ChoiceEndocrinology

Progestin Signals through DARPP

Science's STKE  15 Feb 2000:
Vol. 2000, Issue 19, pp. tw11
DOI: 10.1126/stke.2000.19.tw11

Female sexual receptivity in mice and rats is mediated by the progestin receptors. Mani et al. found that antisense nucleotides to DARPP-32, a dopamine- and cAMP-regulated protein, as well as DARPP-32 knockout mice, demonstrated decreased sexual receptivity in response to stimulation of progestin receptors or dopamine receptors. The data suggest that the dopamine and progestin pathways converge at the level of DARPP-32 to regulate sexual receptivity.

Mani, S.K., Feinberg, A.A., O'Callaghan, J.P., Snyder, G.L., Allen, P.B., Dash, P.K., Moore, A.N., Mitchell, A.J., Bibb, J., Greengard, P., and O'Malley, B.W. (2000) Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. Science 287: 1053-1056. [Abstract] [Full Text]