Editors' ChoiceWeb-Based Consortia

Not Allied with the Alliance?

Science's STKE  15 Feb 2000:
Vol. 2000, Issue 19, pp. tw8
DOI: 10.1126/stke.2000.19.tw8

The Alliance for Cellular Signaling (AFCS), a scientific research initiative promulgated by Alfred Gilman, seeks to completely unravel the signaling networks in B lymphocytes and cardiac myocytes. Naturally, such an ambitious undertaking requires several layers of collaboration, prioritization of work and resources, and coordinated effort to prevent redundant research. In a correspondence to Nature, Haggarty and Ramalho-Santos discuss the organizational structure and experimental strategy of the alliance. In particular, they are concerned with the choice of cell type exemplars, whether multiple hierarchical committees might affect the quality of the alliance's research efforts, and the importance of an international presence within the AFCS community. Bourne and Gilman reply that intense investigation of two cell types will prevent the dilution of research resources and is necessary to obtain the most complete data sets possible for subsequent analyses. Bourne and Gilman go on to discuss the prioritization of the alliance's research, and their expectation that public availability of the data will spur new leads for the entire signal transduction community.

Haggarty, S.J., and Ramalho-Santos, M. (2000) Will cell alliance breed bureaucracy and leave contributors out? Nature 403: 591. [Online Journal]

Bourne, H.R., and Gilman, A.G. (2000) Reply: Will cell alliance breed bureaucracy and leave contributors out? Nature 403: 591. [Online Journal]