Merger of Family Fortunes

Science's STKE  11 Apr 2000:
Vol. 2000, Issue 27, pp. tw6
DOI: 10.1126/stke.2000.27.tw6

Somatostatin and dopamine are important neurotransmitters in the central nervous system. Their actions are mediated by members of a family of G protein-coupled receptors. For many receptors, homodimerization is an important aspect of functional regulation. Rocheville et al. show that this also can apply to two unrelated receptors like the ones for somatostatin and dopamine. The resulting heterodimers create a new type of receptor with increased physiological activity.

Rocheville, M., Lange, D.C., Kumar, U., Patel, S.C., Patel, R.C., and Patel, Y.C. (2000) Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity. Science 288: 154-157. [Abstract] [Full Text]