Editors' ChoiceImmunology

Tec Kinases, from Structure to Function

Science's STKE  25 Apr 2000:
Vol. 2000, Issue 29, pp. tw5
DOI: 10.1126/stke.2000.29.tw5

Tec kinases are a family of nonreceptor tyrosine kinases with important roles in the differentiation, function, and homeostasis of T cells, B cells, and mast cells. Yang et al. discuss the structure of Tec kinases, their regulation, and their signal transduction pathways in this review. Additionally, the authors provide an overview of the genetic mutations in this kinase family and the associated phenotypes in both humans and mice.

Yang, W.-C., Collette, Y., Nunès, J.A., and Olive, D. (2000) Tec kinases: A family with multiple roles in immunity. Immunity 12: 373-382. [Online Journal]