Transcription factors

Regulating Physiology is PPAR for the Course

Science's STKE  30 May 2000:
Vol. 2000, Issue 34, pp. tw5
DOI: 10.1126/stke.2000.34.tw5

Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that have a role in diseases associated with obesity. Unsaturated long-chain fatty acids and eicosanoids are known to act as ligands with different affinities for the three PPAR isotypes: α, β (or δ), and γ. Kersten et al. review the role of each PPAR isotype in normal and abnormal processes and discuss the potential for treating chronic disease states by administering synthetic PPAR ligands. However, the controversy stemming from recent clinical reports on the toxicity of the PPAR agonist Rezulin (troglitazone) indicates that more work is required to develop potentially less harmful PPAR agonists for chronic disease therapy.

Kersten, S., Desvergne, B., and Wahli, W. (2000) Roles of PPARs in health and disease. Nature 405: 421-424. [Online Journal]