Editors' ChoiceImmunology

To B Cell, or Not to B Cell

Science's STKE  30 May 2000:
Vol. 2000, Issue 34, pp. tw7
DOI: 10.1126/stke.2000.34.tw7

The transcription factor PU.1 is essential in B cell and macrophage development and proliferation. DeKoter and Singh show that the level of expression of PU.1 can control which cell fate will result. At low levels, PU.1 protein caused precursor cells to differentiate into B lymphocytes; whereas at high levels of PU.1, the same cells differentiated into macrophages.

DeKoter, R.P., and Singh, H. (2000) Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288: 1439-1441. [Abstract] [Full Text]