Garner et al. have explored the topic of how PDZ domain-containing proteins contribute to synaptic organization and signaling. The review focuses primarily on the structure of the presynaptic density and covers such issues as the role of various PDZ-containing proteins in clustering receptors and contributing to downstream signaling events at glutamatergic synapses, organizing the cytoskeleton, and membrane and receptor recycling.
Garner, C.C., Nash, J., and Huganir, R.L. (2000) PDZ domains in synapse assembly and signalling. Trends Cell Biol. 10: 274-280. [Online Journal]