Editors' ChoiceImmunology

Rac2 in Th1 Cells

Science's STKE  27 Jun 2000:
Vol. 2000, Issue 38, pp. tw7
DOI: 10.1126/stke.2000.38.tw7

Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al. report that the small guanosine triphosphatase Rac2 increased the expression of interferon γ (IFNγ), a cytokine that promotes T cell differentiation, and that it appeared to signal through the mitogen-activated protein kinase p38 and the transcription factor NF-κB.

Li, B., Yu, H. Zheng, W.-P., Voll, R., Na, S., Roberts, A.W., Williams, D.A., Davis, R.J., Ghosh, S., and Flavell, R.A. (2000) Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 288: 2219-2222. [Abstract] [Full Text]