Braking for Damage Control

Science's STKE  11 Jul 2000:
Vol. 2000, Issue 40, pp. tw11
DOI: 10.1126/stke.2000.40.tw11

Toxicological insults to DNA often lead to nucleotide mutations and DNA strand breaks that require repair before the next round of DNA synthesis and mitosis. Without DNA repair, mitosing cells might die or become transformed. The G2-phase cell-cycle checkpoint provides time for cells to determine whether repair is required. This response is mediated through proteins that bind DNA and send signals for a delay in DNA synthesis. Much research has been done on elucidating the signaling that occurs during the G2 checkpoint period. O'Connell et al. review what is known about the molecular mechanisms involved and discuss the physiological role of cyclin/Cdk kinase inhibitors during the checkpoint.

O'Connell, M.J., Walworth, N.C., and Carr, A.M. (2000) The G2-phase DNA-damage checkpoint. Trends Cell Biol. 10:296-303 [Online Journal]