Editors' ChoicePhysiology

A More Intricate Clock in Fungi

Science's STKE  11 Jul 2000:
Vol. 2000, Issue 40, pp. tw4
DOI: 10.1126/stke.2000.40.tw4

The transcriptional feedback loop that controls the fundamental daily rhythm of biological organisms has proven to be more intricate than expected. Now Lee et al. show that the fungus Neurospora joins the fruit fly and mouse in having two interlocked feedback loops at the core of the circadian clock. The clock component frequency has a positive effect on another clock component, white collar-1 and -2 levels, in addition to its previously described inhibitory effect on its own transcription. This extension of the two-loop pattern to a fungus indicates the generality of this organization.

Lee, K., Loros, J.J., and Dunlap, J.C. (2000) Interconnected feedback loops in the Neurospora circadian system. Science 289: 107-110. [Abstract] [Full Text]