Perspective

Cyclic ADP Ribose as a Calcium-Mobilizing Messenger

Science's STKE  18 Jul 2000:
Vol. 2000, Issue 41, pp. pe1
DOI: 10.1126/stke.2000.41.pe1

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Abstract

This Perspective by Galione and Churchill is one in a series on intracellular calcium release mechanisms. The authors review the evidence for cyclic adenosine diphosphate ribose (cADPR) being a second messenger involved in regulating intracellular calcium. In addition, the physiological stimuli and responses mediated by cADPR are discussed. The Perspective is accompanied by a movie showing a calcium wave triggered by cADPR.

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