Steroid Receptor and Molecular Chaperone Encounters in the Nucleus

See allHide authors and affiliations

Science's STKE  25 Jul 2000:
Vol. 2000, Issue 42, pp. pe1
DOI: 10.1126/stke.2000.42.pe1

You are currently viewing the abstract.

View Full Text


Steroid hormone receptors interact with several different molecular chaperones. DeFranco and Csermely discuss how the molecular chaperones p23 and Hsp90 may serve to regulate the activity of the ligand-bound steroid receptors within the nucleus. The authors hypothesize that these chaperone proteins may have a proactive role in promoting recycling of receptors once they have interacted with chromatin and in allowing rebinding of ligand once the receptors have been recycled.

View Full Text