Steroid Receptor and Molecular Chaperone Encounters in the Nucleus

Science's STKE  25 Jul 2000:
Vol. 2000, Issue 42, pp. pe1
DOI: 10.1126/stke.2000.42.pe1

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Steroid hormone receptors interact with several different molecular chaperones. DeFranco and Csermely discuss how the molecular chaperones p23 and Hsp90 may serve to regulate the activity of the ligand-bound steroid receptors within the nucleus. The authors hypothesize that these chaperone proteins may have a proactive role in promoting recycling of receptors once they have interacted with chromatin and in allowing rebinding of ligand once the receptors have been recycled.

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