Cell Biology

Refilling the Stores

Science's STKE  25 Jul 2000:
Vol. 2000, Issue 42, pp. tw7
DOI: 10.1126/stke.2000.42.tw7

G proteins (proteins that bind GTP, guanosine 5'-triphosphate) are involved in vesicle endocytosis and exocytosis in a variety of non-neuronal cells. Takahashi et al. analyzed the contribution of G proteins to fast synaptic neurotransmitter release. They introduced several nonhydrolyzable GTP analogs into the giant nerve terminals at the calyx of Held. The rate of recovery from synaptic depression was significantly influenced by these analogs. G proteins help refill synaptic vesicles after massive exocytosis.

Takahashi,T., Hori, T., Kajikawa, Y., and Tsujimoto, T. (2000) The role of GTP-binding protein activity in fast central synaptic transmission. Science 289: 460-463. [Abstract] [Full Text]