Editors' ChoiceAging

Aging and Energy Metabolism

Science's STKE  08 Aug 2000:
Vol. 2000, Issue 44, pp. tw8
DOI: 10.1126/stke.2000.44.tw8

Work in several model organisms suggests that there is a link between aging and energy metabolism. Ashrafi et al. identified sip2 as a gene involved in sensitizing yeast to nutrient deprivation and in controlling yeast life-span. Sip2p is an N-myristoylated protein that acts as an adaptor for the kinase Snf1p, which is required for the induction of glucose-repressed genes in response to glucose deprivation. Deletion of sip2 decreases the life-span of yeast in a manner characteristic of accelerated aging. Genetic analysis and overexpression of Snf1p suggest that the accelerated aging due to loss of Sip2p results from increased activity of the kinase Snf1p. Furthermore, deletion of sip2 resulted in increased hexokinase activity and increased energy pools consistent with a model for aging in which there is a shift in metabolism toward energy conservation.

Ashrafi, K., Lin, S.S., Manchester, J.K., and Gordon, J.I. (2000) Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae. Genes Dev. 14: 1872-1885. [Abstract] [Full Text]