Editors' ChoiceApoptosis

Moving in for a Kill

Science's STKE  22 Aug 2000:
Vol. 2000, Issue 46, pp. tw2
DOI: 10.1126/stke.2000.46.tw2

The TR3 protein (also named nur77 or NGFI-B) is a member of the nuclear hormone receptor family and is required for T cell receptor-induced apoptosis. These receptors are thought to act primarily as ligand-dependent transcription factors. However, Li et al. found that TR3 function does not require the DNA binding domain of the protein. Instead, TR3 promotes apoptosis by translocating to the mitochodria, where it causes release of cytochrome c.

Li, H., Kolluri, S.K., Gu, J., Dawson, M.I., Cao, X., Hobbs, P.D., Lin, B., Chen, G., Lu, J., Lin, F., Xie, Z., Fontana, J.A., Reed, J.C., and Zhang X. (2000) Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 289: 1159-1164. [Abstract] [Full Text]