Editors' ChoiceImmunology

Imaging Immunological Synapses

Science's STKE  29 Aug 2000:
Vol. 2000, Issue 47, pp. tw10
DOI: 10.1126/stke.2000.47.tw10

Immunological synapses arise at contact zones between antigen-presenting cells and T cells. Synapses have distinct organization and are composed of T cell receptors interacting with major histocompatibility complex-peptide entities surrounded by various potentiating coreceptors and signaling molecules that migrate into the synapse through cytoskeleton-dependent processes. Krummel et al. have extended initial studies in lipid bilayers to explore the architecture and the extraordinary dynamics of immunological synapse formation by real-time video microscopy of whole cells containing green fluorescent protein chimeras.

Krummel, M.F., Sjaastad. M.D., Wülfing, C., and David, M.M. (2000) Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289: 1349-1352. [Abstract] [Full Text]