Control of T Helper Cell Differentiation--in Search of Master Genes

Sci. STKE, 12 September 2000
Vol. 2000, Issue 49, p. pe1
DOI: 10.1126/stke.2000.49.pe1

Control of T Helper Cell Differentiation--in Search of Master Genes

  1. Chen Dong and
  2. Richard A. Flavell
  1. C. Dong is at the Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  2. R. A. Flavell is at the Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, 310 Cedar Street, New Haven, CT 06520, USA. E-mail: fran.manzo{at}yale.edu

Abstract

Naïve T helper (TH0) cells can differentiate into one of two distinct populations: TH1 and TH2. Each population is characterized by the expression of specific cytokines and their ability to participate in cell-mediated or humoral immune responses. Recent efforts at identifying the molecular mechanisms through which TH0 cells become TH1 or TH2 cells have been promising. A number of transcription factors, including GATA-3 and T-bet, have been identified that promote the differentiation of TH0 cells and the maintenance of the differentiated cell phenotype. Dong and Flavell review recent findings on proteins that control the fate of TH0 differentiation, whether by promotion or inhibition, and discuss the role of epigenesis in the differentiation process.

Citation:

C. Dong and R. A. Flavell, Control of T Helper Cell Differentiation--in Search of Master Genes. Sci. STKE 2000, pe1 (2000).

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells
J. J. O''Shea, and W. E. Paul
Science 327, 1098-1102 (26 February 2010)

Natural killer receptors: the burden of a name
H. Veiga-Fernandes, D. Kioussis, and M. Coles
JEM 207, 269-272 (15 February 2010)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882