Cell Biology

Integrins Controlled by VEGF

Science's STKE  31 Oct 2000:
Vol. 2000, Issue 56, pp. tw3
DOI: 10.1126/stke.2000.56.tw3

Angiogenic growth factors like VEGF (vascular endothelial cell growth factor) promote the formation of new blood vessels. Their effects on processes such as cell motility and cell-cell interaction are similar to the effects of integrins, the adhesion receptors that mediate interactions with the extracellular matrix. Byzova et al. show that in human umbilical vein endothelial cells, these similarities can be explained by effects of VEGF on integrin "activation." Treatment of cells with VEGF increased the affinity of the integrin αvβ3 for its ligands. In M21 melanoma cells, integrins were constitutively active because of autocrine effects of VEGF. In these cells, the activating signal from VEGF to integrins appeared to be mediated by phoshoinositide-3 kinase and the protein kinase Akt.

Byzova, T.V., Goldman, C.K., Pampori, N., Thomas, K. A., Bett, A., Shattil, S.J., and Plow, E.F. (2000) A mechanism for modulation of cellular responses to VEGF: Activation of the integrins. Mol. Cell 6: 851-860. [Online Journal]