Reviewing the Paths to Aging

Science's STKE  14 Nov 2000:
Vol. 2000, Issue 58, pp. tw8
DOI: 10.1126/stke.2000.58.tw8

Two reviews discuss signal pathways that influence the aging process. Finkel and Holbrook cover how oxidants contribute to the aging process, the cellular signaling pathways that lead to altered cellular redox state, and the pathways activated in response to oxidative stress. Guarente and Kenyon describe mechanisms of aging learned from studies in the genetically tractable model systems budding yeast and the nematode, Caenorhabditis elegans. In yeast, the pathway linking metabolic rate to aging appears to converge at a protein involved in gene silencing. Major pathways identified in C. elegans include the regulation of life-span by hormone signaling and sensory stimulation.

Finkel, T., and Holbrook, N.J. (2000) Oxidants, oxidative stress, and the biology of ageing. Nature 408: 9-17. [Online Journal]

Guarente, L., and Kenyon, C. (2000) Genetic pathways that regulate ageing in model organisms. Nature 408: 25-32. [Online Journal]