Positive Versus Negative Signaling of LET-23: Regulation Through the Adaptor Protein, SEM-5

Science's STKE  19 Dec 2000:
Vol. 2000, Issue 63, pp. pe2
DOI: 10.1126/stke.2000.63.pe2

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Worby and Margolis highlight advances in our understanding of signaling from growth factor receptors using the worm Caenorhabditis elegans as a model organism. ARK-1, a cytoplasmic tyrosine kinase, appears to be a negative regulator of multiple pathways in C. elegans. The authors discuss several models for how this negative regulation may occur. The adaptor protein (Grb2 in mammals or SEM-5 in C. elegans) may serve as a regulated scaffold for the binding of other signaling proteins that include both positive (Ras) and negative (ACK) regulators. Thus, Grb2 may function in a cellular decision point for transducing the incoming signals.

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