Wnts, Signaling and Sulfates

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Science's STKE  25 Sep 2001:
Vol. 2001, Issue 101, pp. pe32
DOI: 10.1126/stke.2001.101.pe32

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Questions remain about the signaling pathways that control pattern formation during development. Blair describes how sulfated glycosaminoglycans affect several developmentally important signaling pathways, including Wnt-Wingless, Fibroblast growth factor, Hedgehog, and Bone morphogenetic protein-4 signaling. A new secreted sulfatase, Qsulf1, regulates the sensitivity of vertebrate cells to Wnts, possibly by modifying the sulfation of glycosaminoglycans.

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