Making Signals Stick

Science's STKE  25 Sep 2001:
Vol. 2001, Issue 101, pp. tw346
DOI: 10.1126/stke.2001.101.tw346

In T cells, adapter proteins couple the T cell receptor (TCR) to multiple cellular signaling pathways. T cells also depend on cellular adhesion through integrins to perform many of their tasks, and Peterson et al. and Griffiths et al. show that the adapter SLAP-130/Fyb is directly involved this process. Using mice genetically deficient in SLAP-130/Fyb, both groups observed that this protein was not required for inducing TCR-mediated calcium flux and protein tyrosine kinase activation, but was needed for clustering and activation of the integrin, LFA-1, which led to cellular adhesion. This process occurred in the presence of normal TCR-induced actin polymerization, which suggests that SLAP-130/Fyb couples TCR-dependent motility of the cytoskeleton with integrin activation.

E. J. Peterson, M. L. Woods, S. A. Dmowski, G. Derimanov, M. S. Jordan, J. N. Wu, P. S. Myung, Q.-H. Liu, J. T. Pribila, B. D. Freedman, Y. Shimizu, G. A. Koretzky, Coupling of the TCR to integrin activation by SLAP-130/Fyb. Science 293, 2263-2265 (2001). [Abstract] [Full Text]

E. K. Griffiths, C. Krawczyk, Y.-Y. Kong, M. Raab, S. J. Hyduk, D. Bouchard, V. S. Chan, I. Kozieradzki, A. J. Oliveira-dos-Santos, A. Wakeham, P. S. Ohashi, M. I. Cybulsky, C. E. Rudd, J. M. Penninger, Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 293, 2260-2263 (2001). [Abstract] [Full Text]