Editors' ChoiceNeurobiology

Unusual Dendritic Inhibition

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Science's STKE  02 Oct 2001:
Vol. 2001, Issue 102, pp. tw359
DOI: 10.1126/stke.2001.102.tw359

Dopaminergic neurons in the substantia nigra express dopamine transporters in their dendrites. However, the function of these transporters is not fully understood. Falkenburger et al. (see the Perspective by Blakely) combined electrophysiology and amperometry to study dopamine-mediated inhibitory postsynaptic currents. Dopamine can be released from dendrites, and this release was inhibited by the reuptake blocker GBR 12935. In this preparation, a distinctive mechanism causes dendro-dendritic inhibition through reversal of normal dopamine transport.

B. H. Falkenburger, K. L. Barstow, I. M. Mintz, Dendrodendritic inhibition through reversal of dopamine transport. Science 293, 2465-2470 (2001). [Abstract] [Full Text]

R. D. Blakely, Dopamine's reversal of fortune. Science 293, 2407-2409 (2001). [Full Text]