Cell Signalling - The Proteomics of It All

Sci. STKE, 9 October 2001
Vol. 2001, Issue 103, p. pe33
DOI: 10.1126/stke.2001.103.pe33

Cell Signalling - The Proteomics of It All

  1. Keith Ashman1,
  2. Michael F. Moran2,
  3. Frank Sicheri1,
  4. Tony Pawson1, and
  5. Mike Tyers1
  1. 1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada, M5G 1X5.
  2. 2 MDS Proteomics, 251 Attwell Drive, Toronto, Canada, M9W 7H4.
  1. Corresponding author: E-mail. tyers{at}mshri.on.ca; Tel., 416-586-8371; Fax, 416-586-8869.


A challenge for biomedical scientists today is to arrive at an understanding of cellular behavior on a global scale. The advent of DNA microarrays has greatly facilitated discovery of gene expression profiles associated with different cellular states. The problem of understanding cellular signaling at the level of the interacting proteins is in some ways more challenging. Ashman et al. discuss the current methods available for studying protein interactions on a global scale, as well as directions for the future. Technical hurdles exist at many stages, from the isolation of protein complexes, to the determination of their composition, to the software and databases needed to analyze the results of large-scale, high-throughput datasets. Ashman et al. suggest that, with advances in technology and cooperation among academia and industry, a global protein interaction map that underlies cellular behavior will emerge as an essential resource for basic and applied research.


K. Ashman, M. F. Moran, F. Sicheri, T. Pawson, and M. Tyers, Cell Signalling - The Proteomics of It All. Sci. STKE 2001, pe33 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882