Is Dimerization Of Chemokine Receptors Functionally Relevant?

Science's STKE  16 Oct 2001:
Vol. 2001, Issue 104, pp. pe34
DOI: 10.1126/stke.2001.104.pe34

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Chemokines activate lymphocytes by initiating signaling cascades through cell surface receptors that couple to heterotrimeric GTP-binding proteins. Thelen and Bagglioni describe why the recent proposal that these receptors form heterodimers and activate the Jak kinases for transducing signals should be viewed with caution.

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