Perspective

Highlights of Alternative Splicing Regulation Session: Yes, No, Maybe--A History of Paradigm Shifts

STKE  23 Oct 2001:
Vol. 2001, Issue 105, pp. pe35
DOI: 10.1126/stke.2001.105.pe35

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Highlights from the Sixth Annual Meeting of the RNA Society, Banff, Alberta, Canada, 29 May to 3 June 2001.

Abstract

Cooper summarizes the discussions and presentations from the session entitled "Control of Splice Site Selection" held at the Sixth Annual Meeting of the RNA Society. Paradigms are shifting as experiments show that some of the proteins involved in regulating splicing can act as splicing enhancers or repressors, depending on the cellular context. The complex interactions among the ribonucleoproteins (RNPs) and proteins, and the role of cis elements, in controlling cell-specific splicing are highlighted. The importance of properly regulated splicing is emphasized by examples of disease pathologies in which alternative splicing is aberrant.

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