γδ T Cells Get Under the Skin

Science's STKE  23 Oct 2001:
Vol. 2001, Issue 105, pp. tw395
DOI: 10.1126/stke.2001.105.tw395

T cells bearing the γδ T cell receptor reside in large numbers within the epidermis of the skin. The growing evidence that γδ T cells contribute to dermal integrity is supported by the study by Girardi et al., who show these lymphocytes can protect against cutaneous malignancy. Thus, in the absence of γδ T cells, mice coped poorly with experimentally induced forms of skin carcinoma. Induction of malignancy correlated with the increased amounts of the protein Rae-1, which contributed to the killing of carcinoma cells by a γδ T cell line in vitro. Binding studies revealed that Rae-1 interacts with the NKG2d receptor on γδ T cells, which suggests that this ligand may be a functional homolog of tumor-related MICA/B proteins in humans. Pardoll provides a Perspective on the article.

M. Girardi, D. E. Oppenheim, C. R. Steele, J. M. Lewis, E. Glusac, R. Filler, P. Hobby, B. Sutton, R. E. Tigelaar, A. C. Hayday, Regulation of cutaneous malignancy by γδ T cells. Science 294, 605-609 (2001). [Abstract] [Full Text]

D. M. Pardoll, Stress, NK receptors, and immune surveillance. Science 294, 534-536 (2001). [Full Text]