β-Arrestin and Mdm2, Unsuspected Partners in Signaling from the Cell Surface

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Science's STKE  27 Nov 2001:
Vol. 2001, Issue 110, pp. pe41
DOI: 10.1126/stke.2001.110.pe41

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Mdm2 is a ubiquitin-protein ligase known to ubiquitinate p53, promoting its degradation by the ubiquitin-proteasome system. Shenoy and co-workers showed that Mdm2 can act as a key factor in the sequestration of the cell surface β2-adrenergic receptor (β-AR) through interactions with β-arrestin. Strous and Schantl discuss how Mdm2 may be a switch connecting extracellular signals mediated through G protein-coupled receptors (GPCRs) to p53 and its functions in apoptosis and cell cycle progression.

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