Editors' ChoiceCheckpoints

Coordinated Effort Against DNA Damage

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Science's STKE  27 Nov 2001:
Vol. 2001, Issue 110, pp. tw436
DOI: 10.1126/stke.2001.110.tw436

The protein kinase ATR is implicated in the signaling pathway that causes cells to arrest the cell division cycle when damage to DNA is detected. Cortez et al. describe a new human protein that interacts with ATR and is a substrate for the kinase. ATRIP (for ATR-interacting protein) has sequence similarity to the yeast proteins that interact with the yeast homologs of ATR, but unlike the yeast proteins, ATRIP and ATR regulate each other's expression in human cells. Such tight coordination of expression is consistent with the authors' demonstration that both proteins are required for proper responses to DNA damage and that ATR is required for viability of human somatic cells.

D. Cortez, S. Guntuku, J. Qin, S. J. Elledge, ATR and ATRIP: Partners in checkpoint signaling. Science 294, 1713-1716 (2001). [Abstract] [Full Text]