Perspective

New Responsibilities for the PI3K Regulatory Subunit p85α

Science's STKE  16 Jan 2001:
Vol. 2001, Issue 65, pp. pe1
DOI: 10.1126/stke.2001.65.pe1

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Abstract

Class IA phosphoinositide-3 kinases (PI3Ks) are heterodimeric enzymes that regulate many signal transduction pathways. The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids. Recent studies present evidence for an additional role for p85α in the regulation of actin cytoskeleton. Okkenhaug and Vanhaesebroeck discuss these results and ask whether experiments describing p85α knockout mice need to be reinterpreted.

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