Editors' ChoiceChannels

Kinase and Channel in One Package

Science's STKE  13 Feb 2001:
Vol. 2001, Issue 69, pp. tw8
DOI: 10.1126/stke.2001.69.tw8

An ion channel that contains its own functional protein kinase domain has been cloned and characterized by Runnels et al. The channel, called TRP-PLIK, is most closely related to melastatin, a channel protein associated with progression of melanocytic tumors. TRP-PLIK also appears to interact with the key signaling enzyme phospholipase C-β1. Mutagenesis studies of the kinase domain and the dependence of channel conductance on intracellular adenosine triphosphate both indicate that the kinase activity of the channel regulates channel function. This channel likely links signaling from the cell membrane to the control of proliferation or of other calcium-dependent processes within the cell.

L. W. Runnels, L. Yue, D. E. Clapham, TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291, 1043-1047 (2001). [Abstract] [Full Text]