Editors' ChoiceImmunology

Antigen Recognition Cuts Both Ways

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Science's STKE  27 Feb 2001:
Vol. 2001, Issue 71, pp. tw3
DOI: 10.1126/stke.2001.71.tw3

B cells appropriate help from T cells by expressing class II molecules, which display antigenic peptides to specific receptors expressed by the T cells. These receptors are wired up to complex intracellular signaling pathways that launch a program of activation and differentiation in the T cell upon the recognition of appropriate antigen. Lang et al. provide evidence that the interaction between T cell receptor and class II molecule is not simply a one-way exchange of information. Signals could be delivered back to the B cell via the class II molecules. This process depended on their association with the signaling chains of the B cell antigen receptor. This process may play a role in regulating T cell-B cell cooperation during immune responses to antigen.

P. Lang, J. C. Stolpa, B. A. Freiberg, F. Crawford, J. Kappler, A. Kupfer, J. C. Cambier, TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-α/β dimers. Science 291, 1537-1540 (2001). [Abstract] [Full Text]