Nuclear Receptors

Fatty Acid Shuttle

Science's STKE  06 Mar 2001:
Vol. 2001, Issue 72, pp. tw10
DOI: 10.1126/stke.2001.72.tw10

Peroxisome proliferator-activated receptors (PPARα, PPARβ, and PPARγ) are transcription factors activated by fatty acids and some antidiabetogenic drugs. Wolfrum et al. identified liver fatty acid binding protein (LFABP) as a protein that binds to the same ligands as does PPARα and that interacts directly with PPARα and PPARγ. They propose that LFABP, which can be found in both the cytoplasm and the nucleus, acts as a shuttle to deliver the PPAR agonists to the nuclear-localized PPAR receptors. In support of this model, transactivation of a PPAR reporter construct increased linearly with the amount of LFABP expressed.

C. Wolfrum, C. M. Borrmann, T. Börchers, F. Spener, Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus. Proc. Natl. Acad. Sci. U.S.A. 98, 2323-2328 (2001). [Abstract] [Full Text]