Two Mammalian Mitotic Aurora Kinases: Who's Who?

Science's STKE  13 Mar 2001:
Vol. 2001, Issue 73, pp. pe1
DOI: 10.1126/stke.2001.73.pe1

You are currently viewing the abstract.

View Full Text


Several serine-threonine kinases related to the Ipl1p kinase in budding yeast, termed aurora kinases, have been cloned recently. Their characterization revealed them to be important regulators of mitotic functions, including (i) the separation of the centrosome, (ii) assembly of the spindles, and (iii) segregation of the chromosomes. The Perspective by Descamps and Prigent delves into the latest observations on aurora kinases in humans and the specific roles of each kinase within the process of mitosis.

View Full Text