Editors' ChoiceDevelopment

TGF-β Receptor Type I and Angiogenesis

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Science's STKE  10 Apr 2001:
Vol. 2001, Issue 77, pp. tw3
DOI: 10.1126/stke.2001.77.tw3

Transforming growth factor-β (TGF-β)-deficient mice have greatly impaired vascular and hematopoietic development, but because TGF-β can signal through several heterodimeric receptors, it is not known whether defects in angiogenesis and hematopoiesis are mediated by the loss of specific receptor subunits. Larsson et al. created TGF-β type I receptor (TβRI)-deficient mice and found that yolk sacs from embryonic lethal mice had defective angiogenesis, leading to an impaired vasculature. Endothelial cells from TβRI-/- mice exhibited aberrant migration and defective fibronectin production in vitro, which correlated with the impaired vasculature in vivo. Hematopoiesis in TβRI-/- mice was normal, indicating that TβRI function is critical for proper angiogenesis but not for hematopoietic development.

J. Larsson, M.-J. Goumans, L. Jansson Sjöstrand, M. A. van Rooijen, D. Ward, P. Levéen, X. Xu, P. ten Dijke, C. L. Mummery, S. Karlsson, Abnormal angiogenesis but intact hematopoeitic potential in TGF-β type I receptor-deficient mice. EMBO J. 20, 1663-1673 (2001). [Abstract] [Full Text]