Editors' ChoiceAging

Insulin-Like Pathways and Aging

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Science's STKE  17 Apr 2001:
Vol. 2001, Issue 78, pp. tw10
DOI: 10.1126/stke.2001.78.tw10

In the nematode Caenorhabditis elegans, mutations in the daf pathway, which normally regulates an inactive hibernation-like life phase, can prolong life-span dramatically. The daf pathway is homologous to the insulin pathway of higher organisms, and the ability of caloric restriction to increase the life-span of rodents suggests further links. Fabrizio et al. take this demonstration a step further by screening for mutants that control life-span in nonreplicating yeast. They identify Sch9, a kinase similar to the Akt/PKB kinase in the insulin signaling pathway of mammals, as well as the yeast homolog of adenylate cyclase. The insulin-like signaling pathway appears to be a prime regulator of life-span, likely through its control of whole-organism metabolism.

P. Fabrizio, F. Pozza, S. D. Pletcher, C. M. Gendron, V. D. Longo, Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290 (2001). [Abstract] [Full Text]